Chromosome+1

Welcome To Chromosome 1! Chromosome 1 is 246 million base pairs long!
 * ([|Chromosome 1], April 22, 2012) **

- // **Genome: The Autobiography of a Species in 23 Chapters** //
 * "We are descended not from one ancestral Luca, but from the whole community of genetic organisms. Life, says Woese, has a physical history,**
 * not a genealogical one".**
 * (Ridley, M., 1999, Pg 20) **



Gene 1: NGF or Nerve Growth Factor (beta polypeptide) is the gene that provides that instructions for making the protein nerve growth factor beta. The protein serves an important role in the development and survival of neurons mainly the ones that transmit pain, the temperature, and touch. This gene is essential as without it we would not be able to feel pain and have a sense of hot and cold. With the benefits of the Gene there are a few downfalls with mutations, one mutation in the NGF gene courses hereditary sensory and autonomic neuropathy type V. This is a condition that in with the person would have the inability to feel pain and touch sensations along the lack of the ability to sense temperature.
 * ([|NGF], April 28, 2012) **

Gene 2: ASMP or asp (abnormal spindle) homolog, microscephaly associated (Drosophila) is the gene that provides a protein that is involved in cell division. The protein is found in the cells and tissues in the body, but is crucial in the division of the cells that take part in the development of the brain. Mutations in this gene lead to many issues for the person, one result of a mutation can lead to abnormal head size and a small brain. As a result the person will have intellectual disabilities along with delayed development.
 * ([|ASPM], April 28, 2012) **

Usher Syndrome Usher syndrome sadly does not make you a better singer, Usher Syndrome is disease that comes from chromosome 1 the most common symptoms are the loss of hearing and the slow loss of vision with in the first few years of life. The dieses is found in three forms, Usher Syndrome 1, 2 and 3.Those effected by Usher Syndrome 1 are usually born deaf and the loss of vision takes place in childhood they usually also have difficulties learning to sit properly and also learn to walk much later than usual. In Usher Syndrome 2 hearing and vision loss starts in late adolescence or adulthood. In Usher Syndrome 3 the effects start only after a few decades of living. The syndrome occurs 4 per 100,000 people and also it has been traced to happen more likely to people of Jewish ancestry.
 * ([|Usher Syndrome], April 29, 2012) **

Interesting Facts! Chromosome 1 is the largest human chromosome, it is over 8% of the human genome! There are over 350 human diseases linked with chromosome 1, They include neurological and developmental disorders along with many different cancers.
 * ([|Facts-Sanger Institute], April 30, 2012) **

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 * 1) Chromosome 1 - Genetics Home Reference. (n.d.). Genetics Home Reference - Your guide to understanding genetic conditions. Retrieved April 22, 2012, from [|http://ghr.nlm.nih.gov/chromosome/1]
 * 2) Ridley, M. (1999). Personality. Genome: the autobiography of a species in 23 chapters(pp. 11-22). New York: Harper Collins.
 * 3) NGF-Genetics Home Reference. (n.d.). Genetics Home Reference - Your guide to understanding genetic conditions. Retrieved April 28, 2012, from []
 * 4) ASPM-Genetics Home Reference. (n.d.). Genetics Home Reference - Your guide to understanding genetic conditions. Retrieved April 28, 2012, from
 * 1) " Usher syndrome  - Genetics Home Reference." //Genetics Home Reference - Your guide to understanding genetic conditions //. N.p., n.d. Web. 29 Apr. 2012, from __http://ghr.nlm.nih.gov/condition/usher-syndrome __
 * 2) J,e."Human Genome Project: Chromosome 1- Wellcome Trust Sanger Institure." Home page- Wellcome Trust Sanger Institute. N.p., n.d. Web. 30 Apr.2012 from []